Essay Topics About Friendship Can Improve Your College Writing

Essay Topics About Friendship Can Improve Your College WritingWhen selecting essay topics about friendship, students should be cognizant of the following: When writing a short essay, the focus must be on the subject and the topic. When selecting essay topics about friendship, the student must try to write an essay that is not too long but that does not overstay its welcome. The essay topic should show students how relationships can enhance or diminish their lives.Students who are taking a survey program are required to gather information from other students about their experiences. Students should not write an essay with no connection to the survey question. Since students are entering the college as freshmen, they should focus on the topic of their college orientation program in order to prepare for a career.When preparing for a survey program, students should ensure that they include questions that reflect their learning style. By including questions that allow them to expand their knowledge, students are more likely to learn from their essays. As students progress in their studies, they are likely to expand their career choices and move into other fields. An essay with topics about friendship will keep students interested in continuing their education.Students who select essay topics about friendship should choose those topics that show the relationship between the writers and the audience. Students should think about the style and content of their essays. Students should think about how students may perceive the essay's content, as well as how the essay writer will relate to the reader.A good article can capture the interest of readers; however, a great article can further your career. Students who enter the college setting as freshmen should consider writing an essay on topics about friendship so that they will not be left behind.Students should plan their essay topics about friendship according to their career goals and focus their writing on the issue th at interests them most. A good essay topic will give students some specific direction and will help them further their education.By preparing to enter the college environment as a freshman, students can better develop their writing skills. Using some suggestions from others' essays and college essay topics about friendship, students can learn how to better approach writing assignments and enhance their writing abilities.

The Storm Essays - Cloud, , Term Papers, Research Papers

The Storm Nature's tears, the pounding rain, Cruelly mimic my resounding pain. Opaque clouds conceal her soul, But mine is open, a bottomless hole That never heals, can never be cured, Love dies inside, so rest assured I shall no longer flood the land With endless droplets wiped by hand. Wait! Suddenly the horizon brightens, Hope and fear in my heart heightens. The myth of the clouds with the silver lining Breaks the spell that was once confining, For now I feel my spirits rise As nature herself answers my cries. No longer shall I mope and mourn, For he has mended my heart that was torn.

Essay on Body Modification D

Essay on Body Modification D Essay on Body Modification D Body Modification. The term can have weird and scary implications for people who have no personal interest or experience in the subject, and it can be all too easy to judge or malign its participants and practitioners. But in reality, to willfully modify one’s body is to take part in a culture and tradition that spans class, race, and human history like nothing else. In the simplest terms, â€Å"body modification† means to deliberately alter one’s physical appearance, though people usually assume the phrase applies only to such practices as tattooing and piercing or the more esoteric branding and scarification. However, all one has to do is look at society’s present definition of aesthetic to discover that almost all of us engage in some form of body modding or other. For instance, it would be pretty hard to find a woman these days who doesn’t have her ears pierced, and one of the most involved, long-term, and committed types of body modification, b odybuilding, is not often even considered to be so. And, of course, surgical body modification has become extremely common in the form of cosmetic surgery, but that’s rarely considered shocking or odd unless the procedure goes wrong or the resulting aesthetic is outside of the socially accepted standard of beauty. In every group of humans in known and recorded history, there have been members who modified their bodies. The reasons behind their choices vary widely, even within a single society. In many cultures around the world, social status, group affiliations, and wealth are advertised with jewelry and adornments; in others, deeper meanings are behind the punctures, scars, and tattoos they wear. In certain African cultures, for instance, rites of passage successfully completed are denoted by scarring all over the face and body, painfully administered by the practiced hand of an elder or religious leader, the discomfort bravely endured by the new initiate, and the marks worn proudly ever after. In some groups of people in India and Southeast Asia, genital modifications are sought after by devotees of the arts of love, and desired and preferred by their partners. And, of course, in almost every culture there are modifications that are done purely for aesthetic reasons–adornment and beautification of both sexes and all genders, striving towards an accepted goal or standard of human perfection within their culture. It’s a commonly accepted misconception that body piercing is a relatively recent trend or fashion, but ear piercing, of course, is incredibly common in almost every culture throughout history, with a huge range of legends, myths, and meanings behind the jewelry worn and its placement. Nostril piercing has been documented in the Middle East as far back as 4,000 years. The fashion continued in India in the sixteenth century, and is still widely practiced there to this day. Both ear and nostril piercing and jewelry are mentioned in t he Bible: Genesis 24:22, Isaiah 3:21.(New International Version) And piercings in other parts of the body, such as labret or lip piercings, are widely practiced often in the form of enlarged piercings and lip discs. Tribes across Africa, in Southeast Asia, and in North and South America all participate in lip piercing. And today, of course, all of these types of piercings are still practiced in the West, though the primary motivation behind them is aesthetic adornment and enhancement. Tattooing, as we know it, can be documented as far back as 3300 BCE as seen in the discovery of Otzi the Iceman in 1991 and ancient Egyptian mummies bearing tattoos of animals and various creatures. (PBS) The practice, however, is believed to have originated over 10,000 years ago. The mechanics of tattooing have changed a bit over the years, and the pigments and inks used have wildly improved in recent times, but whether hand-tapped, poked with a single needle, or administered with the telltale buzz of a modern tattoo machine, the basic reasons behind the choice to

The educator as a public intellectual Essay Example | Topics and Well Written Essays - 1750 words

The educator as a public intellectual - Essay Example In principle, teachers are the second guide and protector after the parent. Significantly, they mold the child by introducing him/her to the foundations of education and making the student conversant with how to interact with others. Similarly, teachers’ contributions to society are by molding and developing the future generation in accordance with the social and cultural structures of the given community. For instance, it is the role of teachers to provide moral and intellectual leadership to the youth by preparing them to be critical thinkers and active citizens in society. Significantly, life is a journey encompassing experience and knowledge gained. Therefore, one meets individuals who build their characters and adds some benefits to their lives as a whole. For instance, too many people in Baltimore Mr. Jim Beglin are nothing short of a public intellectual. Furthermore, being a sociology teacher Mr. Beglin has been able to enlighten the students on the need for better social behavior, planning, and political consciousness. Therefore, with Mr. Beglin as their educator students at Bishop Walsh School have been able to quench their thirst for knowledge while at the same time get to be influenced by right living subscribing to the conscious doctrine of life. Mr. Beglin subscribes to the philosophy of integrity, and hard work pays off. In essence, by equipping and always reminding his students of the need to be true to themselves and only rely on what one has worked for has improved the students’ behavior and attitude to an admirable level. Therefore, through motivating his students and assuring them of the significant benefits that accrue to an individual, who strives to earn and live on his/her sweat. Significantly, this doctrine has been spread to how the students carry themselves and act in society, hence influencing even more members of the community. In principle, Mr. Beglin noting the need to educate more people in Baltimore, he started hosting

A research paper on Penelope Fitzgerald and her book the Gate of

A on Penelope Fitzgerald and her book the Gate of Angels - Research Paper Example Passed on from her parents, Penelope eventually developed interest in literature. Although Penelope published her first biography at the age of 58 years old (Courtney), she officially started her literary career at the age of 60 years old when she published her first novel entitled â€Å"The Golden Child† (Courtney; Harvey-Wood). As a novelist, Penelope was knowledgeable on literature. Having written and won the Booker Prize with Offshore, she was able to catch a large group of readers. As a competitive writer, she managed to write outstanding novels that are self-sufficient (Saunders). It was in 1990 when Penelope published the book â€Å"The Gate of Angels†. In this novel, Penelope amazed a lot of people for knowing things about atomic physics and issues related to probationary nursing (Barnes). As a novelist, Penelope was an expert in making use of the right term and phrases when describing not only the main characters in the novel but also when pointing out the irony in a situation. As one of Penelope’s best novels, the story of â€Å"The Gate of Angels† is about a young Cambridge University physicist named Fred Fairly who fell in love with nurse Daisy Saunders after a bicycle accident. Basically, the accident happened when both of them were bicycling along the same road. In this novel, Penelope was able to assemble the cast of the story in such a way that the reader would clearly know how Fred Fairly and Daisy Saunders interact with each other. The fact that Penelope described the past lives of the two main characters that made the readers understood the gap between Fred and Daisy. Even though Penelope has been known as one of the most promising novelist of the olden times in England, some of her works has been a subject to positive criticism (Los Angeles Times b). As compared to the works of other novels like the English novelist Martin Amis or Evelyn Waugh, the novels written by Penelope are often

Economic Impact Of Technology Interventions Streptokinase Economics Essay

Economic Impact Of Technology Interventions Streptokinase Economics Essay About 14 million patients in India suffer from heart attacks every year. Of these, 2.8 million patients can benefit from a clot buster drug which would save the patients life and provide room for further treatment such as medical stents if so required. Coronary heart disease claims over a million lives every year in India. There is a need for a safe and affordable clot buster drug. At the turn of the century, clot buster drug formulations were either imported or based on imported bulk drug and formulated domestically. They were expensive, equivalent to eighteen months (tPA) to two months (Streptokinase) of per capita income at that time. Cost matters more in India unlike in countries with universal health insurance as most Indians spend out of own pocket for health expenses. Given Indias prowess in generic drugs, the production capacity gap in an area of health emergency with severe consequences seems an anomaly. The gap stems from the fact that clot buster drugs are biotechnology dr ugs which require competencies quite different from those of the usual drugs based on chemical synthesis. CSIR-IMTECH, Chandigarh made efforts to develop a process to produce clot buster drugs. Initial efforts were unsuccessful, in part due to the complex nature of the animal sources based protein drug. Subsequent teams picked up the challenge again, chose a simpler molecule and after some misses, could develop a process for natural streptokinase and then recombinant streptokinase, both harnessed from micro-organisms. The misses were important steps providing crucial learning for the process development. Streptokinase technology was transferred to industry partners, natural Streptokinase to Cadila Pharma and recombinant Streptokinase to Shasun Pharma. Implementing the technology on the shopfloor faced difficulties. In the case of recombinant streptokinase, regulatory approvals took time to obtain. The knowing-doing gap was bridged by closing the competency gap through sustained engagement between the CSIR-IMTECH scientists and the managers and technology staff of the licensees. Persevera nce, team perseverance, allowing mistakes, dynamic learning from disciplined failure, give-and-take by both the scientists team and the industrial practitioners team, and a can-do, must-do, done mind-set were the keys to success. Leadership steering at both the Lab and the Industry with a commitment to collaborate and continual collaborating was crucial. This led the transition from the lab scale to industrial scale. The respective products were launched in 2001 and 2009. The results are quite encouraging. Prices have dropped (by 65 percent, to less than one month of per capita income), availability has increased, access to a life-saving medicine has risen, and patients have realized a worth of over Rs. 16,000 crores due to the CSIR-IMTECH/licensees Streptokinase. The economic impact, or the additional benefit that would be lost if this CSIR-IMTECH Streptokinase technology intervention had not been there, is assessed based on medical impact of Streptokinase and using per capita income to be Rs. 2180 crores. The Lab itself accomplished net earnings valued at Rs.1.8 crores and the Industry partners together realized value addition of Rs. 17 crores. Innovating for affordable healthcare is inclusive innovation. The benefits to patients eclipse the benefits to those who generated the technology intervention. This pursuit of innovation continues. CSIR-IMTECH has taken the science of clot-buster drugs to a level where improved Streptokinase (smarter streptokinase) molecules will have the advantages of the far more expensive animal cell line based tPA but will be much more affordable. Similarly, while access has expanded (about 120,000 standard doses), there remain millions of patients in need of this life-saving drug. More needs to be done. Introduction Heart attacks, strokes, respiratory and cardiac failure have a common enemy in blood clots in the bloodstream that can block blood supply to the heart muscle, any part of the brain or the lungs. The consequence of blockage is damage to the heart muscle, the brain cells, or the lung tissue which is usually irreversible and debilitating, if not fatal. Extreme consequences can arise if the treatment is not administered within a window of few hours (3-4.5 hours, Klabunde (2007), Hacke et. al. (2008)). Then, the heart or brain tissue, as the case may be, gets damaged which is mostly irreversible. Treatments range from clot-dissolving medication to surgical intervention such as angioplasty or insertion of stents and open chest bypass surgery. Clot busters, as clot dissolving drugs are called, attack the clot itself to dissolve it and restore blood supply. Angioplasty is an invasive and expensive procedure where blocked arteries are opened up using medical stents thus making more space for the blood supply to be restored. Similarly, bypass surgery is invasive and very expensive (see appendix 1). Prevention in high-risk patients (hardened and narrowed/blocked arteries) is via blood thinner drugs that reduce blood density allowing blood to flow through the reduced space. Despite preventive treatment, clots can form and occlusion in blood vessels can occur. Then, clot buster drugs are life saviours. In India, more than a million patients die due to coronary heart disease every year (appendix 1). Until the year 2001, no domestic production of clot-busters existed. The formulations were imported: among others, the lead formulations of Streptokinase Kabinase by Kabi Pharmacia, Sweden and Streptase by Hoechst Marion Roussel, Germany were priced then between Rs. 3000 to Rs. 4000 per vial (Krishnan (2000)). The dominant drug in this class of drugs, Tissue Plasminogen Asctivator (tPA) cost more than Rs. 30,000 per vial. Thus, clot buster drugs were expensive and the supply was short of requirement. In terms of per capita income at that time, this amounted to eighteen months of income for tPA and about two months of income for Streptokinase. The Streptokinase market was about 21 thousand vials of standard dose of 1.5 miu  [1]  . Lack of affordability could have restricted access. Given Indian pharmaceutical industrys prowess in generic drugs, realized through strengths in organic chemicals synthesis and process engineering, this raises the question about the obstacles. The Indian pharmaceutical industry was essentially based on chemical entities whereas clot buster drugs are based on biotechnology  [2]  which was almost non-existent in India around the turn of the century. Thus, access to affordable life-saving clot buster drugs was limited domestically. To make it affordable, it had to be produced domestically. To produce it domestically, a suitable technology had to be developed. The technology had then to be transitioned from a laboratory scale to an industrial scale. As in the case of affordable chemical drugs, the impetus of finding solutions and creating domestic capacity also came from CSIR Labs. In the case of generic chemical drugs, the core scientists came from Labs such as the NCL, Pune, IICT, Hyderabad and CDRI, Lucknow. These scientists and their industry contemporaries developed and implemented safe and cost effective technologies in a short time span. In the case of biotechnology, processes are being developed by IMTECH, Chandigarh and IICB, Kolkata among others. A program at IMTECH tapped into finding a solution to the problem of an affordable clot buster drug. The program has roots in projects dating back to 1989. The scientists examined the prevalent clot buster drug tissue Plasminogen Activator (tPA) but then chose instead an alternate less complex protein Streptokinase for development. This study examines the benefits realized from the Streptokinase project, specifically, the natural Streptokinase biotechnology drug licensed to Cadila Pharma and the recombinant Streptokinase drug technology licensed to Shasun Pharma Limited, to quantify the value creation and to assess the economic impact. The Industry The Indian pharmaceutical industry is among the top science based industries and focused on quality affordable drugs. It is estimated to be USD 21 billion or about Rs. 105,000 crores with exports accounting for about 40 percent (USD 8.7 billion) in 2009-10 (DOP (2011, 2012)). The industry is growing at over 10 percent per year. It is the sixth largest industry in India ranked by contribution to GDP (CSO (2011)). Globally, it ranks 3rd in terms of volume of production (10 percent of global share) and 14th largest in terms of value (1.5 percent of global share). A reason for the low value share is the lower cost of drugs in India 5 to 50 percent less than in developed countries. Thus, the Indian drugs and pharmaceutical industry is focused on affordable drugs. The Indian pharmaceutical industry is diverse. The number of units is quoted at over 20,000. However, the actual number of drug manufacturing licenses issued is about 5877 (GOI (2003))  [3]  . Registered factories are about 3500 (CSO (2011)), the rest being smaller unregistered units. The units are spread across India and provide depth that accounts for the 10 percent global volume share. Apart from MNCs such as Glaxo Smithkline, Pfizer, Astra Zeneca, several Indian companies Ranbaxy, Dr. Reddys, Cipla, Lupin and others have global operations. Biotechnology based drugs have taken root and are growing. Companies such as Biocon, Serum Institute of India, Panacea Biotec, and Reliance Life Sciences have adopted biotechnology. The biotechnology industry value exceeds Rs. 20,000 crores in 2011-12 (BioSpectrum-ABLE Biotech Survey 2012). Many Indian companies maintain the highest standards in purity, stability and international safety, health and environmental protection in production and supply of bulk drugs to buyer companies, who in turn are subject to stringent assessment by regulatory authorities in importing countries. These companies have secured regulatory approvals from USFDA, MHRA-UK, TGA-Australia, MCC-South Africa for their plants. Quality with certification is also a feature among many Indian pharmaceutical companies. During the last decade, the industry has embraced new technologies and adapted to regulatory regimes more aligned to international regulatory regimes. New business models have emerged to cope with and thrive in this environment. All of these have a bearing on the development of a domestic clot buster drug, namely, Streptokinase. With the advent of product patents in India from the 2005 amendment to the Patents Act, the focus has shifted from process engineering to drug discovery. Process engineering remains important. Several drugs will go off patent over the next few years and supply of cost effective quality generics would benefit the industry and the consumers. However, drug discovery is the new mantra. Drug discovery is a highly uncertain multi-million multi-year activity. For every one new drug molecule approved, the pipeline requires about twelve molecules for clinical trials candidacy. For every molecule reaching clinical candidacy, the pipeline of molecules is three molecules based on current success rates at each stage. The total costs spiral to over USD 600  [4]  million per new drug molecule in the USA over a span of a decade. Patent protection allows recovery of the investment but also makes the drug expensive. In India, the cost per new drug molecule can drop to less than USD 150 million due to lower costs (such as those of clinical trials). This lower cost is encouraging Indian drug enterprises to engage in drug discovery as they adapt to the product regime. However, even at the reduced cost in India, the drug would still be expensive and out of reach of many Indians. Drugs capacity building in India appears to be addressing reduction in costs and so also in the time span for drug discovery. Specialization along the chain of drug discovery via outsourcing is one emerging business model. Thus, RD is being shaped by Contract Research Organizations (CROs), Drug Discovery Development (DDD) and Clinical Trials Organizations (CTO). Manufacturing is by large integrated companies as also by Contract Manufacturers. Marketing is also by Contract Marketers and co-marketing alliances (IBEF (2010), KPMG (2006)). While regulatory changes may be the trigger for drug discovery, demand for drugs for Indian diseases is also an impetus. Chief among these are drugs for infective diseases found in India but not much in developed countries such as tuberculosis, malaria, typhoid, cholera etc. These diseases are far more prevalent in developing countries such as India where affordability is a key issue. Profits from patented multi-billion drug molecules will be tough to realize for these diseases. Thus, effective new molecules for these diseases would have to be developed within India. A major initiative underway in this regard is the Open Source Drug Discovery (OSDD) project of CSIR which seeks to harness talent across boundaries, cutting costs and hopes to reduce drug discovery time. It is open source and thus drug molecules found will be distributed without the higher price due to profits associated with patents. Costs will be cut down to the collaborative nature of the initiative. Incentives to col laborators are based on contributing to drug discovery for debilitating diseases and the recognition among peers. Also important are drugs for the so called lifestyle diseases such as diabetes (about 50 million diabetics in India as per Ramachandran et. al. (2010)) and hypertension (65 million hypertension patients in India as per Gupta (2004)), both high risk factors for emergencies such as heart attacks, strokes and respiratory failure. India is estimated to have about 14 million patients that suffer from myocardial infarction or heart attacks every year, of which 80 percent patients may not be receiving proper medical care (Financial Express (2002)). About 20 percent (2.8 million) of the cardiac patients population in India could use a clot buster drug. Only a fraction (about 200, 000 or under 10 percent) of these patients undergo bypass surgeries or angioplasty. The rest of the patients (2.6 million) could be treated with clot buster drugs administered within a window of 3-4.5 hours to the patient. Recall that there are over a million deaths every year due to coronary heart disease in India. With a growing number of diabetes and hypertension patients in India, and so increasing chances of blood vessel occlusion related deaths, having access to an affordable clot buster drug is going to be increasingly more important. An added advantage is the possibility of exports of these drugs since the diseases addressed are prevalent globally. The Technology Gap, Development and Commercialization A domestic clot buster drug was missing, as discussed earlier. The choice among three prevalent drugs narrowed to Streptokinase. Streptokinase is a 47kD  [5]  protein composed of 414 amino acids produced by several strains of beta hemolytic streptococci. It dissolves a clot occluding blood supply through a 3-step process. First, Streptokinase forms a complex with plasminogen (Pg). This 1:1 complex (the Partner Pg) rapidly becomes proteolytically active. Second, the Partner Pg complex acts on substrate Pg molecules in circulation to convert them to plasmin (Pn), the active form of the pro-enzyme Pg. Plasmin is a protease that is capable of breaking apart cross-links between fibrin molecules, which provide the structural integrity of blood clots. So, third, the plasmin rapidly dissolves the pathological clot occluding blood supply to the heart muscle in case of myocardial infarction, to brain tissue in case of stroke or to the lungs in case of respiratory failure. The Lab, Research Capacity and Technology Development Technology development has been enabled by science research and ongoing (and predecessor) projects at CSIR-IMTECH. The focus is science and technology related to microbial products. A key area is recombinant gene technology based products. One initiative relates to developing a domestic clot buster drug. The initial attempt in late 1980s focused on the prevalent drug tissue Plasminogen Activator (tPA) which is naturally found in the human body in small quantities. Through recombinant gene technology, a pioneer of the field, Professor Collen and his organization Genentech USA produced tPA from animal cell lines in the early 1980s. Attempts to replicate tPA production in IMTECH did not fructify partly due to the volatile external environment prevalent at that time and so the lack of enough scientists to execute the task. During the early 1990s, subsequently, another team of scientists at IMTECH chose an alternative to tPA, namely, Streptokinase for development due to its simpler structure and higher probability of success in developing a novel process for domestic production. The process involved two key competencies protein science and cloning science among others. Technical problems arose again in implementing the recombinant gene technology. The scientists decided to down-shift to developing a process for producing Streptokinase from natural sources. It involves two main processes fermentation (protein production) and purification (separating the protein from the broth, purified to an extent that it is admissible to humans). This effort was successful lending both credibility to the process and boosting the morale of the scientists concerned. The first success helped to delineate the tasks possible from the tasks not possible (appendix 2). This paved the way for producing Streptokinase using re combinant gene technology increasing yield many times over. The key process innovation was the use of 2-step chromatography for purification. Leadership Throughout the years of development spanning 1989 onward, the scientists at CSIR-IMTECH were supported by the science leadership and management comprising four different institute directors and two different director-generals  [6]  . Leadership and institutional continuity combined with scientific ingenuity and perseverance to produce first natural and then recombinant streptokinase. The agenda continues and smart Streptokinase is under development which could be a life-saving and life-enhancing product not only for India and the developing nations but also for the developed countries. The Technology Transfer, Technology Embedding and Commercialization The lab scale success has to be transitioned to industrial scale and commercial success. Subsequent to the transfer of know-how on fermentation and purification processes and the strain, implementation at an industrial scale also faced many hurdles. While the science was established at the Lab with lab scale production, the transition to industrial scale volumes threw up challenges (see appendix 2). As at the Lab level, informed hit and trial, learning from failure, delineating what not to do from what to do helped to transition the technology to industrial scale. Standardization of the industrial biotechnology process entailed initial training, repeated training and embedding the technology in the licensees premises. IMTECH engaged with the licensees and remained engaged thereby providing a lot of handholding in the journey from the lab to factory production. This case is an example of disciplined failure where learning from initial failure led to a course change, technological succ ess, commercial success, and then again picking up the more difficult task and taking it to fruition. CSIR-IMTECH first developed a technology to produce natural Streptokinase from Streptococci. It was developed in 4 years by 1998-99, licensed and transferred in 1999-2000 and launched commercially in 2001-2002. The recombinant Streptokinase was developed in 5 years by the year 2001-2002, licensed and transferred in 2002-2003 and commercially launched in 2009-10. Natural Streptokinase know-how was licensed to Cadila Limited for fees of Rs. 20 lakhs and royalty based on ex-factory sales for 5 years. This drug was launched as STPASE injection in year 2001-02. Subsequently, recombinant gene technology was licensed by CSIR-IMTECH to Shasun Pharmaceuticals Limited, Chennai for a fee of Rs. 1 crore and royalty payments based on ex-factory sales for 5 years. The drug was launched in July 2009 and marketed by Lupin Pharma as LUPIFLO. Comparison with prevalent alternate treatments Prior to adoption of Streptokinase for clot-blockade led heart attacks, the treatments were generalized and included oxygenation and intensive care (appendix 1). Subsequent to studies of randomized controlled trials establishing efficacy and superiority of Streptokinase, it was adopted widely specially in Europe. Later, other clot busting drugs were developed. Still later, open heart bypass surgery and then angioplasty using medical stents were developed. Clot buster drugs are more affordable than surgical treatments. Within the class of clot buster drugs, Streptokinase remains the most affordable. Its costs are lower since its production is micro-organism based unlike the others derived from animal cell lines. Comparison with prevalent competing technologies clot-busters Clot-buster drugs in use are tissue plasminogen activator (tPA), Streptokinase, and Urokinase. Streptokinase competes with tissue plasminogen activator (tPA) which is the prevalent clot buster drug. tPA is preferred for its target (blood clot causing blockade) specificity. The advantage of tPA over Streptokinase is in the extent of systemic fibrinogenolysis generated by each. The resultant side effect of bleeding (due to suppression of clot formation by plasmin) can be higher for Streptokinase. However, studies have established that streptokinase is as effective in saving lives in mycocardial infarction as is tPA, despite the nearly ten-fold higher price of the latter. tPA is expensive enough to be inaccessible to most patients for this life threatening condition. Recombinant tPA reduced prices but the cost remains many times over that of Streptokinase. Cost of treatment is of utmost importance as most Indians health expenditure is out of own pocket. Appendix 1 clearly indicates that while the treatments for myocardial infarction vary from Streptokinase to tPA to angioplasty and bypass surgery, for a vast majority of Indians (with annual income about and below the current per capita annual income of Rs. 60,000), the treatment affordable and so possible is administering of Streptokinase. The alternative to Streptokinase would be a mix of morphine, oxygenation, intensive-care. Comparison with prevalent manufacturers Producers of natural Streptokinase, for several years, were only MNCs such as Behring-werke (Germany) and Lederle (USA). In India, before CSIR-IMTECHs intervention, Streptokinase was imported, Streptokinase injections were sold by MNCs Kabinase by Kabi Pharmacia, Sweden and Streptase by Hoechst Marion Roussel, Germany and priced then between Rs. 3000 to Rs. 4000 per vial in year 2000 (Krishnan(2000)). tPA prices varied from Rs. 30,000 per vial in year 2000-01 to about Rs. 19,000 per vial in 2010-11. In India, CSIR-IMTECH licensee Cadila Pharmaceuticals Ltd. manufactured Streptokinase as STPASE at an ex-factory price of Rs. 900 per vial (standard 1.5 miu dose) in 2001-02. The recombinant Streptokinase which has the same biological properties of natural Streptokinase (but much higher yields) was produced by CSIR-IMTECH licensee Shasun Chemicals and Drugs Limited, Chennai at an ex-factory price of Rs. 465 per vial in year 2009-10. This is the bulk drug price. It is marketed as LUPIFLO by Lupin Pharmaceuticals Limited and as STUKINASE by Samarth Pharma among other formulators. Non-CSIR licensee entry also occurred after the first CSIR licensee entered. There were three entrants, two of whom have already exited. The third entrant, Biocon, is successfully producing recombinant Streptokinase and marketing it as Myokinase. Data and Methodology Lab data are obtained from CSIR-IMTECH. Industry data are obtained through questionnaires and interviews. Market data such as sales value and quantity numbers for Streptokinase formulations/brands along with data on company characteristics such as MNC/Indian, date of launch, size of formulation are from the IMS Health India database on Streptokinase. The data are collected at the stockist level and are representative of the Indian pharmaceuticals market with the exception of sales directly from producers/formulators to the hospitals. Given the retrospective nature of this economic impact study, and the difficulties in collecting past data, the initial methodology proposed was a contemporaneous difference analysis between CSIR licensees and comparable enterprises. However, Streptokinase producer data could not be collected despite mailed questionnaires followed up with interviews  [7]  . Instead, for the industry analysis, market sales and volume data for a panel of 20 years are used to estimate a demand function with pooled OLS regressions. The pooled regressions permit segregation of estimates for CSIR licensees from others, and, of estimates over time  [8]  . Benefits of the Technology Intervention Creating Value Benefits to the Lab CSIR-IMTECH developed a technology and plugged a production capacity gap for a life-saving drug. The first of the series of streptokinase molecules established the credibility of CSIR as a solutions provider based on their science rooted program for technology. IMTECH scientists successfully integrated science and application producing more improved molecules and earned fees and royalty in the process. The total value of fees and royalty received is about Rs. 2.5 crores and the investment in terms of salaries and cost of patents is about Rs. 65 lakhs in 2011-12 prices. The internal rate of return on the Labs cash flows for Streptokinase works out to 36 percent  [9]  . Thus, the technology program is quite cost effective for CSIR. Benefits to CSIR Licensees and the Industry The direct benefit to the licensees in terms of value addition thus far (from 2001-02 to 2011-12) is about Rs. 17 crores in 2011-12 prices, the bulk of it, Rs. 16.5 crores, arising from the first licensee Cadila Pharma Limited. The second CSIR licensee Shasun Limited has limited value added from its two years of Streptokinase operations. The first molecule served as a proof-of-concept for the industry and even more as a proof-of-value creation. It was followed by another successful molecule variant and commercial success with that also. From no producer of Streptokinase in year 2000, there are now at least three producers domestically. The third producer Biocon, a non-CSIR licensee, is among three entrants, the other two having exited already. In 2001, before entry of the first domestic producer, CSIR-IMTECH licensee Cadila Pharma, there were about four Streptokinase brands and sales value was about Rs. 6 crores with about 20 thousand vials of standard dose. The value of the Streptokinase industry is over Rs. 20  [10]  crores in 2011 with about 118 thousand vials in terms of the standard dose of 1.5 miu and about thirty brands (including different vial sizes) marketed. While many factors are responsible for this value increase, demonstration of the proof- of-concept (technology works) and the proof-of-value (commercial success) by CSIR-IMTECH scientists and licensees may have been crucial. Without these, the country may still have been importing the drug at much higher prices. To that extent, the country is also saving foreign exchange. The current market price of STPASE is reported to be about Rs. 1000 per vial and the prices of Streptokinase vials from Shasuns bulk drug vary from Rs.715 to Rs. 2300. Myokinase, the third non-CSIR entrant Biocons product, is reportedly selling at a price of about Rs. 2000 per vial. The average market price is about Rs. 1700 per vial (standard 1.5 miu dose). Prices of streptokinase by CSIR-IMTECH licensees are among the lowest in the industry, where over 30 versions of formulations are now being marketed domestically. Industry Competition With increasing market competition, prices drop and sales increase. Competition can be enhanced more by entry of producers. A pioneering paper (Bresnahan and Reiss 1991) developed an empirical framework for measuring the effects of entry in concentrated markets by studying the relationship between the number of firms in the market, market size, and competition. Their analysis suggests that competitive conduct changes quickly as the number of incumbents increases. In markets with five or fewer incumbents, almost all variation in competitive conduct occurs with the entry of the second or third firm. Surprisingly, once the market has between three and five firms, the next entrant has little effect on competitive conduct. In the absence of data on price-cost margins, they develop another key metric the ratio of break-even sales Sn+1/Sn where n refers to the last incumbent producer and n+1 refers to the entrant. This threshold is equal to one in perfectly competitive markets where the minimum efficient scale of production is quite low relative to the market size and there are no entry barriers. In concentrated markets, the threshold of break-even sales ratio is higher than one due to substantial fixed costs as well as entry barriers. A new entrant could incur higher fixed capital cost and/or higher variable costs (such as marketing costs to establish their product and realize sales). With increasing entry, this threshold break-even sales ratio should decline and approach the value of one as in perfect competition. While we do not observe price-cost margins for all three domestic producers of Streptokinase Cadila (entry in year 2001), Biocon (entry in 2008) and Shasun (entry in 2009) we do have information on sales  [11]  and company provided break-even years. Using the Bresnahan and Reiss (1991) framework, the calculation of break-even sales (quantity of vials) ratio is found to be 2.8 for the second entrant (Biocon, relative to first producer Cadila Pharma) and 1.6 for the third entrant (Shasun Pharma, relative to Biocon)  [12]  . This quick examination points to a decreasing value of the break-even sales ratio and fast increasing competition with just three entrants, much in line with the findings of the Bresnahan and Reiss paper. Benefits to the People and the Economy Price Reduction, Affordability and Access

Peace On Manor Farm :: Essays Papers

Peace On Manor Farm The animals lived in peace on the Manor Farm. The owner, Mr. Jones, took advantage of them but they did not know any better. Old Major was one pig that had a dream because he knew that they were getting taken advantage of. He tells the other animals of a life without Mr. Jones and how oppressive the humans are. The animals have this in their mind now but do not take any action really until one day when they are not fed. The men that work for Jones do not feed the animals for over a day. Starving, the animals break into the storage shed where food is kept and begin to eat. Mr. Jones and his men try to beat the animals back with whips. The animals become angry at this mistreatment and turn on the men and drive them off the farm. The animals lock the gate to prevent the human's return. They celebrate and gallop around the farm and they build a fire, which they throw the human's tools and possessions into the fire. They then paint out Manor on the farm sign and change it to say Animal Farm. Then on the barn they paint the Seven Commandments of Animalism. Though the whole incident the pigs lead them. The pigs were the most intelligent of all animals. From the beginning of the rebellion there are two pigs that stood out above the rest as leaders. Their names were Napoleon and Snowball. Snowball takes charge in running the farm. Every animal is equal and gets treated equally. Snowball introduces a plan to build a windmill. Napoleon disagrees with Snowball. During one of Snowball's speeches "Napoleon stood up and, casting a peculiar side long look at Snowball, uttered a high-pitched whimper of a kind no one had ever heard him utter before." (Orwell, page 57) Then nine enormous dogs rush into the barn and dashed straight for Snowball. They chased Snowball away. Up until this point the pigs are good and are equal with all the other animals. Napoleon takes control of the farm and things start to change. Napoleon wants absolute power and uses the dogs for his protection and other purposes. He says that Snowball is a traitor.